Recently a group of researchers from the Instituto de Neurociencias have explained the molecular mechanism of the discomfort that originate in Dry Eyes. The study has been published in the journal Nature Communications.
UMH Professor Carlos Belmonte explained that "until now we knew that the
nervous system is sensitive to increases in the concentration of salts
that in turn causes decreases in the volume of tears of dry eye disease,
but we did not know the molecular mechanism responsible for the
excitation of these nerves."
But this study shows that TRPM8 protein is responsible for the origination of sensations that leads to discomfort and irritation in eye and increased blinking rate.
"We believe the TRPM8 protein is that responsible for the nerve signals reaching the brains in persons with dry eye and they cause increased blinking and sensation of pain," concluded Andrés Parra.
Journal Reference:
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| Photo found on: anthonyliska.com.au |
But this study shows that TRPM8 protein is responsible for the origination of sensations that leads to discomfort and irritation in eye and increased blinking rate.
"We believe the TRPM8 protein is that responsible for the nerve signals reaching the brains in persons with dry eye and they cause increased blinking and sensation of pain," concluded Andrés Parra.
Journal Reference:
- Talisia Quallo, Nisha Vastani, Elisabeth Horridge, Clive Gentry, Andres Parra, Sian Moss, Felix Viana, Carlos Belmonte, David A. Andersson, Stuart Bevan. TRPM8 is a neuronal osmosensor that regulates eye blinking in mice. Nature Communications, 2015; 6: 7150 DOI: 10.1038/ncomms8150
Post Credit
Dr Sharva Pandya
Consultant Ophthalmologist
Jai Drishti Eye Hospital, Udaipur (Raj)
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